The Ledger

Hypochondriacs

Costs, trials, and records of failure. US registry data.
Does not reflect the records of other countries, which also exist. Source: NIH Reporter · ClinicalTrials.gov · FDA · US federal data only

Disease Snapshot

Disease	NIH Total	Trials	Enrolling	Terminated	FDA Approvals	As of
▶HIV/AIDS Medicine & Health	$44,719,683,128	1062	176	23	—	2026-03-30
Trial Status Breakdown 176 Enrolling 754 Completed 23 Terminated 1 Suspended 108 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $44,719,683,128 61347 grants · 2015–present
▶Cardiovascular disease Medicine & Health	$36,487,484,015	1051	262	35	—	2026-03-30
Trial Status Breakdown 262 Enrolling 539 Completed 35 Terminated 1 Suspended 214 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $36,487,484,015 65508 grants · 2015–present
▶Alzheimer's disease Medicine & Health	$36,313,125,389	1014	322	66	—	2026-03-30
Trial Status Breakdown 322 Enrolling 500 Completed 66 Terminated 6 Suspended 120 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $36,313,125,389 54007 grants · 2015–present
▶Obesity Medicine & Health	$25,617,188,107	1062	264	20	—	2026-03-30
Trial Status Breakdown 264 Enrolling 627 Completed 20 Terminated 1 Suspended 150 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $25,617,188,107 50120 grants · 2015–present
▶COVID-19 Medicine & Health	$25,594,225,975	1034	85	47	—	2026-03-30
Trial Status Breakdown 85 Enrolling 559 Completed 47 Terminated 6 Suspended 337 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $25,594,225,975 23698 grants · 2015–present
▶Leukemia Medicine & Health	$20,732,935,205	1007	337	50	—	2026-03-30
Trial Status Breakdown 337 Enrolling 448 Completed 50 Terminated 7 Suspended 165 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $20,732,935,205 37207 grants · 2015–present
▶Breast cancer Medicine & Health	$18,756,534,877	1033	340	39	—	2026-03-30
Trial Status Breakdown 340 Enrolling 461 Completed 39 Terminated 3 Withdrawn 3 Suspended 187 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $18,756,534,877 39829 grants · 2015–present
▶Lung cancer Medicine & Health	$17,155,300,803	1011	373	48	—	2026-03-30
Trial Status Breakdown 373 Enrolling 383 Completed 48 Terminated 5 Suspended 202 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $17,155,300,803 33575 grants · 2015–present
▶Diabetes mellitus, type 2 Medicine & Health	$12,706,289,591	1033	159	41	—	2026-03-30
Trial Status Breakdown 159 Enrolling 667 Completed 41 Terminated 1 Withdrawn 2 Suspended 163 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $12,706,289,591 26721 grants · 2015–present
▶Prostate cancer Medicine & Health	$8,822,098,933	1029	408	52	—	2026-03-30
Trial Status Breakdown 408 Enrolling 446 Completed 52 Terminated 5 Suspended 118 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $8,822,098,933 18088 grants · 2015–present
▶Lymphoma Medicine & Health	$8,518,817,205	1035	389	52	—	2026-03-30
Trial Status Breakdown 389 Enrolling 432 Completed 52 Terminated 6 Suspended 156 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $8,518,817,205 15943 grants · 2015–present
▶Opioid use disorder Neuroscience	$8,250,866,446	817	328	16	—	2026-03-30
Trial Status Breakdown 328 Enrolling 399 Completed 16 Terminated 6 Suspended 68 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $8,250,866,446 11816 grants · 2015–present
▶Schizophrenia Neuroscience	$8,012,649,476	1061	189	46	—	2026-03-30
Trial Status Breakdown 189 Enrolling 666 Completed 46 Terminated 5 Suspended 155 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $8,012,649,476 16438 grants · 2015–present
▶Pancreatic cancer Medicine & Health	$6,666,128,608	1012	376	40	—	2026-03-30
Trial Status Breakdown 376 Enrolling 396 Completed 40 Terminated 1 Suspended 199 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $6,666,128,608 14274 grants · 2015–present
▶Melanoma Medicine & Health	$6,485,802,296	1050	379	67	—	2026-03-30
Trial Status Breakdown 379 Enrolling 468 Completed 67 Terminated 1 Withdrawn 3 Suspended 132 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $6,485,802,296 13632 grants · 2015–present
▶Colorectal cancer Medicine & Health	$6,231,836,088	1036	320	46	—	2026-03-30
Trial Status Breakdown 320 Enrolling 422 Completed 46 Terminated 5 Suspended 243 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $6,231,836,088 13509 grants · 2015–present
▶Parkinson's disease Neuroscience	$5,898,089,604	1039	291	40	—	2026-03-30
Trial Status Breakdown 291 Enrolling 513 Completed 40 Terminated 2 Suspended 193 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $5,898,089,604 12689 grants · 2015–present
▶Ovarian cancer Medicine & Health	$5,311,402,172	1001	336	44	—	2026-03-30
Trial Status Breakdown 336 Enrolling 429 Completed 44 Terminated 2 Withdrawn 5 Suspended 185 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $5,311,402,172 10456 grants · 2015–present
▶Glioblastoma Medicine & Health	$3,361,086,138	817	289	32	—	2026-03-30
Trial Status Breakdown 289 Enrolling 381 Completed 32 Terminated 1 Withdrawn 9 Suspended 105 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $3,361,086,138 7776 grants · 2015–present
▶Major depressive disorder Neuroscience	$3,318,862,078	1049	268	40	—	2026-03-30
Trial Status Breakdown 268 Enrolling 593 Completed 40 Terminated 1 Withdrawn 7 Suspended 140 Unknown NIH Funding by Year '19 '20 '21 '22 '23 '24 '25 '26 $3,318,862,078 6863 grants · 2015–present

Trial Graveyard

No trial obituaries on record yet. The graveyard fills forward from pipeline launch.